亚洲成人涩涩 I 在线播放你懂的 I 污网站在线观看视频 I 日本国产中文字幕 I 久久久久久国产 I 六月婷综合 I av 一区 二区 久久 I 日本丰满熟妇hd I 一级黄片毛片 I 国产一级久久 I 欧美性精品220 I 日本肉感肥臀一二三区 I www国产在线 I 欧美日韩中文另类 I 国产一区二区不卡在线看 I 亚洲国产成人不卡 I 亚洲日本精品一区 I 篠田优中文在线播放第一区 I 国产二区视频在线播放 I 性猛aa久久久 I 成在人av抽搐高潮喷水流白浆 I 日韩aa大片 I 噜噜噜噜噜久久久久久91黄画 I 黄页网站在线看 I 欧美精品久久99久久在免费线 I 18岁禁看奶视频免费看 I 亚洲中文欧美在线视频 I 国产做爰xxxⅹ久久久 I 欧美一区二区视频在线观看 I wwwxxx黄色 I 国产精品12区

sigmaL-天冬酰胺

L-Asparagine monohydrate
Product Number A 8381
Store at Room Temperature
Product Description
Molecular Formula: C4H8N2O3 • H2O
Molecular Weight: 150.1
CAS Number: 5794-13-8
pKa: 2.14 （-COOH）, 8.72 （-NH2）1
pI: 5.431
Specific Rotation: +32.6°
（10 mg/ml, 0.1 M HCl, 20 °C）
Melting Point: 234-235 °C2
Synonyms: （S）-2-aminosuccinic acid 4-amide,
L-aspartic acid 4-amide, α-aminoauccinamic acid,
aspartic acid β-amide2
The amino acid L-asparagine is a structural analog of
L-aspartic acid, where the side chain of the carboxylic
acid moiety is amidated, to give a terminal amine
group. This renders L-asparagine neutral at
physiological pH. The amide group of asparagine is
derived from glutamate, in the reaction of aspartate
and glutamine in the presence of ATP to yield
asparagine and glutamate.3 In vivo, asparagine is
hydrolyzed to aspartate and NH4
+ by asparaginase.4
Asparagine is also an important amino acid in
glycopeptide bonds, via N-glycosyl linkages to the
sugar rings.3
L-Asparagine is used in cell culture media and is a
component of MEM non-essential amino acids solution
（Product No. M 7145）. L-Asparagine has been shown
to enhance ornithine decarboxylase activity in cultured
human colon adenocarcinoma Caco-2 cells and in
cultured IEC-6 intestinal epithelial cells.5,6 Spore
germination in Bacillus subtilis has been increased in
the presence of L-asparagine.7
An isoxazoline RGD mimic plaet GPIIb/IIIa
antagonist has been prepared by chiral synthesis with
L-asparagine as a starting material.8 L-Asparagine
has been utilized in the synthesis of 4-azalysine
building blocks for application to combinatorial
chemistry.9
Precautions and Disclaimer
For Laboratory Use Only. Not for drug, household or
other uses.
Preparation Instructions
This product is soluble in water （50 mg/ml）, with heat
as needed, yielding a clear, colorless solution.
References
1. Molecular Biology Lab, Brown, T. A., ed., BIOS
Scientific Publishers （Oxford, UK: 1991）, p. 29.
2. The Merck Index, 12th ed., Entry# 872.
3. Textbook of Biochemistry with Clinical
Correlations, 5th ed., Devlin, T. M., ed., Wiley-Liss
（New York, NY: 2002）, pp. 97, 680-681, 785-786.
4. Biochemistry, 3rd ed., Stryer, L., W. H. Freeman
（New York, NY: 1988）, pp. 18, 504.
5. Chabanon, H., et al., Increased translation
efficiency and antizyme-dependent stabilization of
ornithine decarboxylase in amino acidsupplemented
human colon adenocarcinoma
cells, Caco-2. Biochem. J., 348（Pt 2）, 401-408
（2000）.
6. Ray, R. M., et al., Interaction of asparagine and
EGF in the regulation of ornithine decarboxylase in
IEC-6 cells. Am. J. Physiol., 276（3 Pt 1）, G773-
780.
7. Cabrera-Martinez, R. M., et al., Effects of
overexpression of nutrient receptors on
germination of spores of Bacillus subtilis. J.
Bacteriol., 185（8）, 2457-2464 （2003）.
8. Zhang L. H., et al., The Enantiospecific synthesis
of an isoxazoline. A RGD mimic plaet GPIIb/IIIa
antagonist. J. Org. Chem., 62（8）, 2466-2470
（1997）.
9. Chhabra, S. R., et al., Homochiral 4-azalysine
building blocks: syntheses and applications in
solid-phase chemistry. J. Org. Chem., 67（12）,
4017-4029 （2002）.
GCY/RXR 8/03
Sigma brand

sigmaL-天冬酰胺 詳細(xì)產(chǎn)品信息可和選購